How it Works

From the point of view of the podiatrist their input is relatively simple.

Step 1

Access the sheet on how to take a sample and follow the instructions.

Step 2

If there are any issues, please contact Dr Hainsworth on 0429 707 492

Step 3

Mail the sample to the receiving address

In the Laboratory

Step 1

Once in the laboratory the DNA will be extracted from the sample and purified using an automated system

Step 2

DNA primers are then added and along with other reagents to the sample, and PCR is then performed to increase the amount of the selected DNA to billions of copies while at the same time keeping the population ratio intact.

Step 3

Illumina Next Generation Sequencing (NGS) sequences the target DNA to produce the sequences present.

Step 4

BIOINFORMATICS is then used to count and tally percentages from all the sequences present. These sequences are then put through a world class data base which identifies each fungus present.

Step 5

The data is assembled into tables and images. These form the basis of the report the clinician will receive. A typical image is below and demonstrates Trichophyton mentagrophytes/interdigitale to be the pathogon involved.

From this stacked histogram it can be seen that Trichophyton mentagrophytes/interdigitale comprises 89.879% of the fungal microbiome. This leads to the conclusion that the nail is a fungal nail and not one that clinically looks like a fungal nail. This particular dermatophyte is most likely susceptible to terbinafine and one of the azoles such as ketoconazole. Some of the other fungi may be adding to the infection and can be researched for their sensitives to particular drugs or treatment modalities

Step 6

Hainsworth Genomics will give treatment suggestions when requested. In Australia T. mentagrophytes/interdigitale is more prominent than T. rubrum and has more likelihood of being resistant to terbinafine. T. rubrum on the other hand is more physically fragile than T. mentagrophytes/interdigitale.

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If you have clinically suspicious fungal nail, metagenomic testing can help you determine with certainty whether fungi are present and if so what species. Through our advanced testing techniques, we can help you form an accurate diagnosis. Simply order a testing kit today to start the process to a certain diagnosis and better patient outcomes.